Manchester City need to react quickly to a first Premier League defeat of the season, by gaining at least a draw at home to Hoffenheim in the Champions League.

The Citizens lost top spot domestically as a result of their 2-0 reverse at Chelsea and Pep Guardiola will want to see a major reaction to that loss, as his side seek to ensure top spot in Group F.

Immediate City response needed

Lyon could yet deny the men from Manchester, but Hoffenheim do not look like a side ready to cause too many problems.

They have won just one of their last six games in all competitions and have not kept a clean sheet in any of their last eight, so you can expect the hosts to get the job done at the Etihad Stadium on Wednesday evening.

City are 1.66 to score over 2.5 goals during the game and they may well have be clinical in front of goal, with their visitors having scored ten goals in their five group games so far.

With Sergio Aguero likely to be missing due to injury, more pressure falls on the shoulders of Gabriel Jesus and he is 1.57 to score at any time.

The other game in Group F is a winner-takes-all affair, with Shakhtar Donetsk able to reach the last-16 if they see off Lyon in Ukraine. Lyon have drawn four in a row in the competition and another level scoreline will be enough to progress, 3.70 for a draw at FT could prove tempting.

All to play for in Amsterdam

Top spot in Group E will be well and truly up for grabs when Ajax play host to Bayern Munich at the Johan Cruyff Arena, with the hosts knowing a win will see them pip the German giants to first place.

Dusan Tadic looks like he could be a pivotal figure in this game, having scored three goals in his last two Champions League outings and the Serbian winger is 3.10 to score at anytime on Wednesday evening. Goals aplenty may well be the order of the day and a small return on both teams to score at 1.50 looks a sound bet.

The history of this fixture offers the home side plenty of positives to take into this game, with Ajax having won three and drawn one in their four previous meetings with Bayern in Amsterdam.

Also, earlier this season, the Dutch side claimed a 1-1 draw in Munich when they probably should have won, so 3.70 for a home win on Wednesday and Ajax to top the group as a result, looks to have plenty of merit.

Juve unlikely to slip up

Juventus need to win at Young Boys to ensure they take top spot in Group H and it is hard to see them failing to do so, with the Swiss side having scored just two goals and secured only one point from their five games to date.

Mario Mandzukic, 2.20 to score at any time, will certainly be looking forward to adding to his tally, having scored in four of his last five games.

Meanwhile, Manchester United head to the Mestalla to take on Valencia, with plenty of focus likely to be on France World Cup winner Paul Pogba.

He has been left out of the starting line-up in the last two games, but will definitely start in Spain and will surely be out to prove a point to head coach Jose Mourinho.

Three of his five goals so far this season have been the first goals in their respective games, so 8.00 for him to score first on Wednesday seems a reasonable option.

Plzen to Czech out Europa League

Real Madrid and Roma have already taken the qualification spots in Group G, leaving Viktoria Plzen and CSKA Moscow to fight it out for third place and a spot in the Europa League after Christmas.

Plzen have the upper hand as they head CSKA on their head-to-head record and while they host Roma in their final game, the Russians head to the Bernabeu to face holders Real.

Plzen are 2.65 to see off a Roma side who have hit the skids in recent weeks and who are without a win in their last four games, with the hosts having lost only one of their last nine in all competitions.

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